Publisher's SynopsisssNew Clinical Genetics continues to offer the most innovative case-based approach to investigation, diagnosis, and management in genomic medicine.ssNew Clinical Genetics is used worldwide as a textbook for medical students, but also as an essential guide to the field for genetic counsellors, physician assistants, clinical and nurse geneticists, and students studying healthcare courses allied to medicine. Readers love the integrated case-based approach which ties the science to real-life clinical scenarios to really aid understanding.ssClinical genetics is a fast-moving field and there have been many advances in the few years since the previous edition was published. This 4th edition has been completely updated and revised to reflect new science, new techniques and new ways of thinking.ssNowhere is this more clear than in the chapter discussing genetics services which is now significantly expanded to reflect the increasing role of genomic medicine and the use of multidisciplinary teams in the management of patients with genetic disorders.ssThe unique case-based structure and format remains the same, but substantial new material has been added to cover:sspolygenic risk scores - now starting to become useful clinical service toolsspreimplantation diagnosissnon-invasive prenatal diagnosisscompanion diagnostics for prescribed drugssliquid biopsies in cancersepigenetics and gene regulationsthe widespread use of next-generation sequencing as a routine diagnostic toolsthe checking of a patient's whole exome for the cause of their problemsPrevious edition: 2015.